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KMID : 0360220180590090861
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Journal of the Korean Ophthalmological Society
2018 Volume.59 No. 9 p.861 ~ p.866
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Poorly Differentiated Neuroendocrine Carcinoma of the Eyelid
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Cho Kyu-Yeon
Kim Jeong-Hee
Lee Dong-Cheol
Suh Yeon-Lim
Woo Kyung-In
Kim Yoon-Duck
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Abstract
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Purpose: To report a case of poorly differentiated neuroendocrine carcinoma of the eyelid.
Case summary: A 70-year-old male presented with a 5-month history of a right upper eyelid mass. The mass appeared as 1.2 × 1.2 cm on the right upper eyelid. A mass excision was performed under frozen section control. The tumor was completely excised with a safety margin clearance and an upper eyelid reconstruction was performed. Histopathological examination revealed a tumor composed of small atypical cells which showed a high nuclear/cytoplasm ratio, nuclear molding, and increased mitotic activity. Immunohistochemical examination revealed positive reactivity for Ki-67, synaptophysin, CD56, and negative reactivity for chromogranin, cytokeratin 20, and thyroid transcription factor-1.
Conclusions: Primary neuroendocrine carcinoma of the eyelid is extremely rare, but the tumor has high malignancy and readily metastasizes. Poorly differentiated neuroendocrine carcinoma should be considered in the differential diagnosis of a rapidly growing eyelid mass.
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KEYWORD
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Eyelid, Merkel cell carcinoma, Poorly differentiated neuroendocrine carcinoma, Small cell carcinoma, Small cell neuroendocrine carcinoma
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